Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html


Study Counts

Type Study_count
Total_Studies 158
interventional 141
Observational 12
Registry 5

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Device 65
Other 17
Drug 14
Procedure 13
Device|Other 10
Biological 5
Drug|placebo 4
Biological|placebo 2
Behavioral 1
Combination Product|Other 1
Combination Product|Procedure 1
Device|Drug 1
Device|placebo 1
Device|Procedure 1
Dietary Supplement 1
Dietary Supplement|placebo 1
Drug|Other 1
Drug|Procedure 1
Other|Procedure 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 52
United Kingdom 12
France 9
NA 8
Canada 4
Israel 4
Ireland 3
Spain 3
Switzerland 3
United States|Canada 3
Austria 2
Brazil 2
Finland 2
Germany 2
Italy 2
Sweden 2
Thailand 2
Belgium|Germany|Netherlands|United Kingdom 1
Czech Republic 1
Denmark|France|Germany|Poland|United Kingdom 1
Denmark|France|Germany|Spain 1
Denmark|Germany|Spain 1
France|United Kingdom 1
Germany|Czech Republic|France|Netherlands 1
Germany|Latvia|Russian Federation|United Kingdom 1
Germany|Netherlands|Poland|United Kingdom 1
Iceland 1
Italy|Poland 1
Mexico 1
Netherlands 1
New Zealand 1
Poland 1
Poland|United Kingdom 1
Portugal 1
Turkey 1
United States|Argentina|Austria|Brazil|Canada|Czechia|Denmark|Germany|Hungary|Italy|Poland|Slovakia|Spain 1
United States|Australia|New Zealand|South Africa 1
United States|Austria|Estonia|Germany|Poland|South Africa|Sweden|United Kingdom 1
United States|Canada|Puerto Rico 1
United States|Canada|United Kingdom 1
United States|Estonia|Germany|Poland|South Africa|United Kingdom 1
United States|New Zealand 1
Uruguay 1

Sites per Study

Site_count Study_Count
1 76
2 10
3 9
4 2
5 3
6 4
7 4
8 4
9 2
10 2
11 1
12 2
13 2
15 2
16 1
17 2
21 1
22 1
27 1
28 1
30 2
33 1
34 1
35 1
43 1
44 1
50 1
56 1
70 1
90 1

Phase

Phase Study_Count
N/A 85
Phase 2 17
Phase 4 13
Phase 3 9
Phase 1 8
Phase 1/Phase 2 7
Early Phase 1 1
Phase 2/Phase 3 1

Number of Arms

Number_of_Arms Count_of_Studies
1 33
2 82
3 10
4 4
5 1
6 1
NA 10

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 50 6.00000 4.0 6.00000 5.0000 250 13.0000 13.00000
1st Qu. 50 25.00000 9.5 33.50000 40.0000 250 148.0000 34.00000
Median 50 60.00000 14.0 40.00000 98.0000 250 225.0000 48.00000
Mean 50 96.68235 20.0 56.85714 128.1765 250 251.7778 96.30769
3rd Qu. 50 128.00000 22.5 44.00000 174.0000 250 425.0000 159.00000
Max. 50 450.00000 64.0 197.00000 426.0000 250 537.0000 266.00000

Trial Group Type

group_type Group_Count
Experimental 114
Active Comparator 83
Placebo Comparator 21
Other 16
No Intervention 14
NA 10
Sham Comparator 6

Intervention Model

intervention_model Study_Count
Parallel Assignment 91
Single Group Assignment 41
Crossover Assignment 7
Factorial Assignment 1
Sequential Assignment 1

Primary Purpose

primary_purpose Study_Count
Treatment 120
Other 4
Prevention 4
NA 4
Basic Science 3
Diagnostic 2
Supportive Care 2
Health Services Research 1
Screening 1

Observational Studies

Studies by Country

Country Study_Count
United States 5
Belgium|Czechia|Germany|Hungary|Poland 1
Colombia 1
France 1
Ireland 1
Italy 1
United Kingdom 1
United States|Canada 1

Sites per Study

Site_count Study_Count
1 9
2 1
30 1
43 1

Enrollment Metrics

Measure Observational
Min 28.00
1st Qu 71.50
Median 100.00
Mean 140.75
3rd Qu 209.75
Max 400.00

Observation Model

observational_model Study_Count
Cohort 7
Case-Control 2
Case-Only 2
Case Control 1

Time Perspective

time_perspective Study_Count
Prospective 11
Retrospective 1

Registries

Studies by Country

Country Study_Count
United States 4
United States|Canada 1

Sites per Study

Site_count Study_Count
1 3
14 1
15 1

Enrollment Metrics

Measure Registries
Min 50.0
1st Qu 82.0
Median 310.0
Mean 37088.4
3rd Qu 10000.0
Max 175000.0

Registry Model

observational_model Study_Count
Case-Only 2
Cohort 2
Other 1

Time Perspective

time_perspective Study_Count
Prospective 5

Follow-up

target_duration Study_Count
1 Month 1
12 Months 1
24 Weeks 1
3 Months 1
5 Months 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT04461132 The Effect of Manual Lymphatic Drainage https://ClinicalTrials.gov/show/NCT04461132 Completed Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey 2019-07-03
NCT04181320 A Multicentre European Study to Evaluate Granulox® Used in the Treatment Pathway of Predominantly Chronic Venous Leg Ulcers (VLUs). https://ClinicalTrials.gov/show/NCT04181320 Recruiting Molnlycke Health Care AB 2022-09-30
NCT03329430 Custom Foot Orthoses & Venous Status https://ClinicalTrials.gov/show/NCT03329430 Completed Universidad de León 2017-12-06
NCT03304834 Treatment of Insufficient Superficial and Perforating Veins of the Lower Limb Using HIFU https://ClinicalTrials.gov/show/NCT03304834 Completed Theraclion 2018-08-30
NCT03286140 Early Venous Reflux Ablation Ulcer Trial https://ClinicalTrials.gov/show/NCT03286140 Completed Imperial College London 2019-03-31
NCT03275831 PluroGel on Wounds of Mixed Etiology https://ClinicalTrials.gov/show/NCT03275831 Recruiting Medline Industries 2021-07-22
NCT03257098 Allogeneic ABCB5-positive Stem Cells for Treatment of CVU https://ClinicalTrials.gov/show/NCT03257098 Recruiting RHEACELL GmbH & Co. KG 2021-06-30
NCT03250247 Chronic Venous Thrombosis: Relief With Adjunctive Catheter-Directed Therapy (The C-TRACT Trial) https://ClinicalTrials.gov/show/NCT03250247 Recruiting Washington University School of Medicine 2021-12-31
NCT03229330 Low-level Light Therapy on Treatment of Venous Ulcers Assesed by Nursing Outcome Classification (NOC) https://ClinicalTrials.gov/show/NCT03229330 Completed Hospital de Clinicas de Porto Alegre 2018-07-31
NCT03200353 Evaluation of Sores Treatment by Oxygenotherapy https://ClinicalTrials.gov/show/NCT03200353 Active, not recruiting Groupe Hospitalier Paris Saint Joseph 2019-01-10
NCT03154619 Efficacy of TR 987, Beta-1,3-1,6-D-glucan, in the Treatment of Chronic Venous Insufficiency Ulcers https://ClinicalTrials.gov/show/NCT03154619 Recruiting SerenaGroup, Inc. 2019-11-30
NCT03077165 Dose-response Relationship Study of S42909 on Leg Ulcer Healing https://ClinicalTrials.gov/show/NCT03077165 Completed Ilkos Therapeutic Inc. 2019-12-12
NCT03050671 Effects of External Leg Compression Devices on Healing and Blood Clotting https://ClinicalTrials.gov/show/NCT03050671 Enrolling by invitation Karolinska University Hospital 2020-03-01
NCT03041844 Enhanced Ultrasound Treatment of Chronic Wounds With Monitoring of Healing and Quality of Life Outcomes https://ClinicalTrials.gov/show/NCT03041844 Recruiting Drexel University 2021-08-31
NCT03021811 EUREKA Italy - Evaluation of Real-life Use of KLOX BioPhotonic System in Chronic Wounds Management https://ClinicalTrials.gov/show/NCT03021811 Completed KLOX Technologies Inc. 2016-12-31
NCT02973893 Study of VF001-DP in Patients With Chronic Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT02973893 Active, not recruiting Factor Therapeutics Ltd. 2018-11-30
NCT02961699 Healing Chronic Venous Stasis Wounds With Autologous Cell Therapy https://ClinicalTrials.gov/show/NCT02961699 Active, not recruiting InGeneron, Inc. 2021-10-31
NCT02896725 Wool-derived Keratin Dressings for Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT02896725 Completed University of Auckland, New Zealand 2019-02-28
NCT02884323 A Study in Patients With Venous Leg Ulcers and Measuring the Effects of Using Gekoâ„¢ Device https://ClinicalTrials.gov/show/NCT02884323 Active, not recruiting Firstkind Ltd 2018-07-16
NCT02790593 Juxta-CuresTM Versus Bandaging for Venous Ulcers https://ClinicalTrials.gov/show/NCT02790593 Completed Colchester Hospital University NHS Foundation Trust 2019-07-29
NCT02729688 Effectiveness of a Pressure Indicator Guided and a Conventional Bandaging in Treatment of Venous Leg Ulcer https://ClinicalTrials.gov/show/NCT02729688 Completed Mahidol University 2017-03-01
NCT02728986 Cost Evaluation of Venous Leg Ulcers Management https://ClinicalTrials.gov/show/NCT02728986 Completed 3M 2018-06-01
NCT02652572 Safety Study to Examine the Systemic Exposure of Granexin® Gel After Topical Application to Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT02652572 Completed FirstString Research, Inc. 2017-12-31
NCT02632695 Physical Activity Interventions for Leg Ulcer Patients https://ClinicalTrials.gov/show/NCT02632695 Completed Medical University of South Carolina 2018-08-31
NCT02626156 Cooling Leg and Foot Ulcer Skin Post Healing to Prevent Ulcer Recurrence https://ClinicalTrials.gov/show/NCT02626156 Completed Medical University of South Carolina 2020-03-31
NCT02609594 Amnioband and Standard of Care vs. Standard of Care Alone in the Treatment of Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT02609594 Recruiting SerenaGroup, Inc. 2018-12-31
NCT02034396 Clinical Implications of Genetic Variations of Venous Stasis Ulceration https://ClinicalTrials.gov/show/NCT02034396 Active, not recruiting University of Pittsburgh 2021-03-31
NCT03277131 DURAFIBER Ag Post-Market Clinical Follow-Up https://ClinicalTrials.gov/show/NCT03277131 Completed Smith & Nephew, Inc. 2019-06-19
NCT03396731 Efficacy Study for Geko Device in VLU Patients https://ClinicalTrials.gov/show/NCT03396731 Recruiting Firstkind Ltd 2020-09-30
NCT02512159 Skin Ulcers Treatment With an Handicraft Topical Device https://ClinicalTrials.gov/show/NCT02512159 Completed Coordinación de Investigación en Salud, Mexico 2014-10-31
NCT02482038 Geko Venous Leg Ulcer Study https://ClinicalTrials.gov/show/NCT02482038 Completed Firstkind Ltd 2018-06-05
NCT02470806 Single-Use Negative Pressure Wound Therapy System vs. Traditional Negative Pressure Wound Therapy System (tNPWT) https://ClinicalTrials.gov/show/NCT02470806 Completed Smith & Nephew, Inc. 2017-11-14
NCT02422017 Topical Timolol Benefit in Venous Ulcers https://ClinicalTrials.gov/show/NCT02422017 Completed Centre Hospitalier Universitaire, Amiens 2016-05-31
NCT02395302 Evaluation of a Dual Action Pneumatic Compression System: Tolerance and Comfort in Patients With Venous Leg Ulcers (VLUs) https://ClinicalTrials.gov/show/NCT02395302 Completed Tactile Medical 2015-09-30
NCT02364921 Effectiveness of Double-layer Compression Therapy in the Healing of Chronic Venous Ulcers in Primary Health Care https://ClinicalTrials.gov/show/NCT02364921 Completed Gerencia de Atención Primaria, Madrid 2018-01-31
NCT02312518 A Prospective, Randomized Clinical Trial of PRP Concepts Fibrin Bio-Matrix in Chronic Non-Healing Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT02312518 Recruiting PRP Concepts, LLC 2021-03-31
NCT02222467 Safety Evaluation of the KLOX BioPhotonic System in Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT02222467 Completed KLOX Technologies Inc. 2015-04-30
NCT02167815 A Multicenter, Post Marketing Clinical Follow up (PMCF) Investigation to Evaluate the Performance and Safety of a Soft Silicone Foam Dressing and to Evaluate the Performance of Standard Care in Exuding Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT02167815 Completed Molnlycke Health Care AB 2015-07-31
NCT02158806 Low Dose Aspirin for Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT02158806 Completed University of Auckland, New Zealand 2017-03-31
NCT02104180 Evaluation of Pain Associated With the Removal of Wound Dressing During Care of Venous Leg Ulcer. Comparison of the Efficacy and Safety of Two Dressings Urgotul and TulleGras https://ClinicalTrials.gov/show/NCT02104180 Completed Mylan Inc. 2016-03-31
NCT02101645 Proof-of-concept Study for Bioimpedance Based Monitoring of Venous Ulcers During Galvanic Stimulation https://ClinicalTrials.gov/show/NCT02101645 Completed Tampere University Hospital 2014-12-31
NCT02092870 Adipose Derived Regenerative Cellular Therapy of Chronic Wounds https://ClinicalTrials.gov/show/NCT02092870 Completed Tower Outpatient Surgical Center 2015-09-30
NCT02020746 Efficacy and Safety Study of EscharEx to Treat (Debride) Hard to Heal Wounds https://ClinicalTrials.gov/show/NCT02020746 Completed MediWound Ltd 2017-12-05
NCT01891760 Long-Term Follow-Up to the DEVO Pivotal Trial of Dermagraft(R) to Treat Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01891760 Completed Shire Regenerative Medicine, Inc. 2012-06-30
NCT01858272 Preliminary Testing of New Treatment for Chronic Leg Wounds https://ClinicalTrials.gov/show/NCT01858272 Completed University of Pennsylvania 2008-08-31
NCT01817218 Feasibility and Safety and Evaluation of the Potential Efficacy of Autologous Platelet-rich Plasma in the Treatment of Vascular Venous Ulcers https://ClinicalTrials.gov/show/NCT01817218 Completed Basque Health Service 2015-01-31
NCT01801891 Surface NeuroMuscular Electrical Stimulation in the Treatment of Chronic Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01801891 Completed Mid Western Regional Hospital, Ireland 2014-09-30
NCT01770509 The Effect of the Cosmetic Cream NMBM on Leg Ulcers - a Pilot Study https://ClinicalTrials.gov/show/NCT01770509 Completed M.D. Lederman Consulting Ltd 2015-02-28
NCT01750749 Cell Therapy for Venous Leg Ulcers Pilot Study https://ClinicalTrials.gov/show/NCT01750749 Completed Hospital de Clínicas Dr. Manuel Quintela 2013-12-31
NCT01743053 A Pilot Trial of the Use of ReCell® Autologous Cell Harvesting Device for Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01743053 Completed Avita Medical 2015-10-31
NCT01737762 Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers >12 cm2 to ≤ 36 cm2 https://ClinicalTrials.gov/show/NCT01737762 Completed Healthpoint 2015-11-30
NCT01673412 Research of Prognostic Factors Associated With Healing of Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01673412 Completed Centre Hospitalier Universitaire, Amiens 2008-06-30
NCT01671748 MIST Ultrasound Therapy Compared to United Kingdom Standard Care for the Treatment of Non-healing Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01671748 Completed Cardiff and Vale University Health Board 2013-12-31
NCT01656889 Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01656889 Completed Healthpoint 2014-12-31
NCT01591434 Study to Evaluate the Performance of AQUACEL® Extra™ in Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01591434 Completed ConvaTec Inc. 2012-09-30
NCT01567150 Wound Fluid Protease Levels During Use of Novel Wound Dressing https://ClinicalTrials.gov/show/NCT01567150 Completed Hollister Incorporated 2014-01-31
NCT01552447 Human Amniotic Membrane Grafting and Standard of Care Versus Standard of Care Alone in the Treatment of Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01552447 Completed MiMedx Group, Inc. 2014-05-31
NCT01549860 Effects of Non Contact Low Frequency Ultrasound in Healing Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01549860 Completed Celleration, Inc. 2014-05-31
NCT01509599 Cooling Lower Leg Skin to Prevent Venous Leg Ulcers in Patients With Poor Vein Circulation https://ClinicalTrials.gov/show/NCT01509599 Completed Medical University of South Carolina 2015-12-31
NCT01497210 EASH Dressing on Chronic Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01497210 Completed ConvaTec Inc. 2012-04-30
NCT01449422 Clinical Trial to Evaluate the Efficacy, Tolerance and Acceptability of URGO Dressing vs a Hydrofibre in the Local Management of Venous or Predominantly Venous Mixed Leg Ulcers. https://ClinicalTrials.gov/show/NCT01449422 Completed Laboratoires URGO 2013-01-31
NCT01372020 Neuromuscular Electrical Therapy in Venous Ulcers https://ClinicalTrials.gov/show/NCT01372020 Completed Faculdade Evangelica do Parana 2011-09-30
NCT01348581 Use of Fish Skin Extracellular Matrix (ECM) to Facilitate Chronic Wound Healing https://ClinicalTrials.gov/show/NCT01348581 Completed Kerecis Ltd. 2012-12-31
NCT01327937 A Post Marketing Study of Apligraf in Non-healing Wounds of Subjects With Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01327937 Completed Organogenesis 2013-11-30
NCT01319123 Evaluate the Impact of Drawtex in Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01319123 Completed Southwest Regional Wound Care Center 2011-08-31
NCT03588130 A Study to Evaluate the Safety and the Efficacy of EscharEx (EX-02 Formulation) in Debridement of Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT03588130 Recruiting MediWound Ltd 2021-08-31
NCT04280679 Treatment of Insufficient Superficial and Perforatring Veins of the Lower Limb Using HIFU https://ClinicalTrials.gov/show/NCT04280679 Recruiting Theraclion 2020-08-31
NCT04240574 Debritom - Micro Water Jet Technology and Wound Healing https://ClinicalTrials.gov/show/NCT04240574 Recruiting Rosalind Franklin University of Medicine and Science 2021-01-31
NCT04046120 Comparison of the Effectiveness of Two Medical Compression Bandage Application Techniques by Measuring Interface Pressures Depending on Whether or Not the Heel is Included in Patients With Open Venous Ulcers https://ClinicalTrials.gov/show/NCT04046120 Recruiting Nantes University Hospital 2021-10-31
NCT04021316 Decellularised Dermis Allograft for the Treatment of Chronic Venous Leg Ulceration https://ClinicalTrials.gov/show/NCT04021316 Recruiting Imperial College London 2020-12-31
NCT04019340 The Impact of a Pluridisciplinary Education Program on Venous Leg Ulcer Size Reduction https://ClinicalTrials.gov/show/NCT04019340 Recruiting School of Health Sciences Geneva 2022-12-31
NCT04018924 Blu Light for Ulcers Reduction https://ClinicalTrials.gov/show/NCT04018924 Completed Emoled 2019-11-17
NCT03935386 Standard Compression Therapy With/Without Application of Skin Allograft (Theraskin) for Venous Leg Ulcer Treatment https://ClinicalTrials.gov/show/NCT03935386 Enrolling by invitation Solsys Medical LLC 2020-12-31
NCT03903692 A Comparative Evaluation of a MPS Dressing and a CMC Dressing on Subjects With Lower Extremity Venous Ulcers https://ClinicalTrials.gov/show/NCT03903692 Recruiting Medline Industries 2021-06-01
NCT03881267 SkinTEâ„¢ in the Treatment of Venous Leg Wounds https://ClinicalTrials.gov/show/NCT03881267 Recruiting Professional Education and Research Institute 2020-09-30
NCT03850496 DESIVI: Dosing of Electrical Stimulation in Venous Insufficiency https://ClinicalTrials.gov/show/NCT03850496 Completed Imperial College London 2016-08-31
NCT03796793 Developing Strategies for Effective Debridement in Patients for Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT03796793 Recruiting University of Miami 2023-04-30
NCT03795064 Immediate Versus Early Endovenous Ablation In Venous Ulcer https://ClinicalTrials.gov/show/NCT03795064 Recruiting Oulu University Hospital 2020-12-01
NCT03716167 Randomized Controlled Trial for Treatment of Pain and Assessment of Wound Healing in Chronic Venous Leg Ulcers Using Near Infrared Laser Therapy https://ClinicalTrials.gov/show/NCT03716167 Active, not recruiting Wake Forest University Health Sciences 2020-10-31
NCT03699072 DermaRepâ„¢ Device in the Treatment of Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT03699072 Recruiting Biovotec AS 2020-01-31
NCT03688841 Negative Pressure Vs. Compression in Venous Ulcers https://ClinicalTrials.gov/show/NCT03688841 Recruiting Western Vascular Institute, Ireland 2019-07-01
NCT03667937 Effectiveness of a Hydrophobic Dressing for Microorganisms’ Colonization and Infection Control of Vascular Ulcers https://ClinicalTrials.gov/show/NCT03667937 Recruiting University of Malaga 2020-12-30
NCT03666754 Early Glue Saphenous Vein Ablation With Compression Versus Compression Alone in the Healing of the Venous Ulcer https://ClinicalTrials.gov/show/NCT03666754 Recruiting Mahidol University 2020-12-31
NCT03662997 Clinical Study to Compare 3 Multi-Layered Foam Dressings for the Management of Chronic Wounds https://ClinicalTrials.gov/show/NCT03662997 Completed Molnlycke Health Care AB 2019-10-01
NCT03640689 DEep VEin Lesion OPtimisation (DEVELOP) Trial https://ClinicalTrials.gov/show/NCT03640689 Recruiting National University of Ireland, Galway, Ireland 2024-09-01
NCT03629236 Study to Evaluate Safety and Efficacy of GrafixPL for the Treatment of Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT03629236 Active, not recruiting Osiris Therapeutics 2020-10-01
NCT03621592 VLU Dressing Study https://ClinicalTrials.gov/show/NCT03621592 Recruiting University of Miami 2020-12-31
NCT03593369 Assessment of the Evolution of Wound Biomarkers in Venous Leg Ulcers Treated With KLOX Biophotonic System https://ClinicalTrials.gov/show/NCT03593369 Recruiting KLOX Technologies Inc. 2020-03-31
NCT03589586 Clinical Effectiveness of DermACELL AWM in Subjects With Chronic Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT03589586 Recruiting LifeNet Health 2020-06-30
NCT03576989 Impact of Omega-3 Fatty Acid Oral Therapy on Healing of Chronic Venous Leg Ulcers in Older Adults https://ClinicalTrials.gov/show/NCT03576989 Recruiting Ohio State University 2023-03-31
NCT03526913 Role of Platelet Rich Plasma in Enhancing Graft Take in Chronic Venous Ulcers https://ClinicalTrials.gov/show/NCT03526913 Completed Menoufia University 2017-09-01
NCT03454698 Education for Venous Leg Ulcer Patients https://ClinicalTrials.gov/show/NCT03454698 Completed School of Health Sciences Geneva 2018-10-31
NCT03420664 Comparison of the Effects of Lower Limb Immobilisation With Cast and Orthosis https://ClinicalTrials.gov/show/NCT03420664 Recruiting Karolinska University Hospital 2020-12-24
NCT03420625 Blood Flow Stimulation in the Lower Limbs by Application of Different External Devices https://ClinicalTrials.gov/show/NCT03420625 Completed Karolinska University Hospital 2017-01-31
NCT01214980 Split Thickness Donor Site Healing With MIST Study https://ClinicalTrials.gov/show/NCT01214980 Completed Celleration, Inc. 2013-07-31
NCT01199588 A Study to Investigate the Efficacy, Safety and Tolerability of Nexagon® as a Topical Treatment for Subjects With Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01199588 Completed OcuNexus Therapeutics, Inc. 2012-12-31
NCT01153633 Trial on the Efficacy of Prontosan Wound Irrigation Solution and Prontosan Wound Gel https://ClinicalTrials.gov/show/NCT01153633 Completed B. Braun Ltd. Centre of Excellence Infection Control 2011-10-31
NCT01138436 A Clinical Study of the Safety and Efficacy of MEBO Wound Ointment in Subjects With Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01138436 Completed Skingenix, Inc. 2011-10-31
NCT01129986 A Post Marketing Clinical Study Utilizing DermaStream and Saline in Venous Ulcers https://ClinicalTrials.gov/show/NCT01129986 Completed EnzySurge 2010-07-31
NCT01084577 AQUACEL® Ag Dressing and Urgotul® Silver Dressing on Healing of Chronic Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01084577 Completed ConvaTec Inc. 2011-01-31
NCT01048307 Effect of Prontosan Wound Irrigation Solution on Venous Ulcers https://ClinicalTrials.gov/show/NCT01048307 Completed Calvary Hospital, Bronx, NY 2010-07-31
NCT00909870 Pivotal Trial of Dermagraft(R) to Treat Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT00909870 Completed Organogenesis 2011-05-31
NCT00858130 Pilot Study for VeinoPlus to Improve Symptoms of Postthrombotic Syndrome (PTS) https://ClinicalTrials.gov/show/NCT00858130 Completed University of North Carolina, Chapel Hill 2009-11-30
NCT00852995 Dose Finding Study of HP802-247 in Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT00852995 Completed Healthpoint 2011-04-30
NCT03818828 Subjects With Non-Healing Venous Leg Ulcers Treated With Standard Care Plus Cryopreserved Human Umbilical Cord (TTAX01) https://ClinicalTrials.gov/show/NCT03818828 Active, not recruiting Tissue Tech Inc. 2020-01-31
NCT00838500 THERMES ET VEINES: Spa for Prevention of Leg Ulcers https://ClinicalTrials.gov/show/NCT00838500 Completed Association Francaise pour la Recherche Thermale 2010-12-31
NCT00832091 Study of Thymosin Beta 4 in Patients With Venous Stasis Ulcers https://ClinicalTrials.gov/show/NCT00832091 Completed RegeneRx Biopharmaceuticals, Inc. 2009-01-31
NCT00823446 Feasibility Study to Evaluate the Safety of Topically Applied Revera in Subjects With Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT00823446 Completed Revalesio Corporation 2010-10-31
NCT04310280 Effects of Local Insulin on Varicose Ulcers for Wound Healing https://ClinicalTrials.gov/show/NCT04310280 Completed Hospital Central “Dr. Ignacio Morones Prieto” 2019-12-31
NCT03736941 Impact of Venotrain UlcerteC Venous Compression Device in the Treatment of Venous Ulcers in Daily Practice https://ClinicalTrials.gov/show/NCT03736941 Recruiting Groupe Hospitalier Paris Saint Joseph 2020-09-30
NCT02009501 V.A.C. VeraFloâ„¢ Instillation Therapy vs V.A.C. Ultaâ„¢ Therapy on Biofilm in Chronically Infected Wounds https://ClinicalTrials.gov/show/NCT02009501 Completed St. Luke’s-Roosevelt Hospital Center 2015-05-31
NCT01754506 Testing Fish Oil Derivatives In Healing Of Chronic Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01754506 Completed Ohio State University 2015-07-31
NCT03112395 Local Application of Combined Optical and Magnetic Stimulation (COMS) for Treatment of Chronic Wounds: Safety Evaluation https://ClinicalTrials.gov/show/NCT03112395 Completed Piomic Medical AG 2020-06-04
NCT02929056 Amniotic Membrane Allograft Application in the Management of Venous Leg Ulcerations https://ClinicalTrials.gov/show/NCT02929056 Enrolling by invitation Prisma Health-Upstate 2020-07-31
NCT02307448 Effectiveness of Autologous Platelet Rich Plasma in the Treatment of Chronic Non-Healing Wounds https://ClinicalTrials.gov/show/NCT02307448 Recruiting ACR Biologics, LLC 2022-12-31
NCT02011503 Use of dHACM in the Treatment of Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT02011503 Completed MiMedx Group, Inc. 2017-08-05
NCT01036438 Evaluating the Efficacy of an Absorbent Foam Dressing Containing Silver (Mepilex Ag) Versus the Same Dressing Without Silver Used on Subjects With Venous Leg Ulcers or Mixed Ulcers https://ClinicalTrials.gov/show/NCT01036438 Completed Molnlycke Health Care AB 2013-10-31
NCT00759434 A New Method of Surgically Treating Varicose Veins and Venous Ulcers - a Study to Assess Clinical and Economic Value https://ClinicalTrials.gov/show/NCT00759434 Completed Hull University Teaching Hospitals NHS Trust 2009-08-31
NCT00720239 Taliderm Dressing for Venous Ulcers https://ClinicalTrials.gov/show/NCT00720239 Completed Medical University of South Carolina 2009-09-30
NCT00663091 A Prospective, Randomized, Double-Blind Controlled Study of WPP-201 for the Safety and Efficacy of Treatment of Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT00663091 Completed Southwest Regional Wound Care Center 2008-05-31
NCT00656383 Effectiveness and Efficiency of Two Models of Delivering Care to a Chronic Wound Population https://ClinicalTrials.gov/show/NCT00656383 Completed Queen’s University 2004-03-31
NCT00628004 Safety Evaluation of Biatain Ibu in Painful Chronic Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT00628004 Completed Coloplast A/S 2009-07-31
NCT00627094 Biatain Ibu vs. Biatain in Painful Chronic Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT00627094 Completed Coloplast A/S 2009-04-30
NCT00570141 OASIS Wound Matrix (Oasis) Mechanism of Action https://ClinicalTrials.gov/show/NCT00570141 Completed Healthpoint 2009-04-30
NCT00558662 Randomized Clinical Trial (RCT) to Compare the Efficacy of Coban 2 Versus SSB in the Treatment of Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT00558662 Completed 3M 2009-04-30
NCT00521027 Study Comparing VERSAJET With Conventional Surgical Procedures in the Removal of Unhealthy Tissue From Lower Limb Ulcers https://ClinicalTrials.gov/show/NCT00521027 Completed Smith & Nephew, Inc. NA
NCT00485329 Assessment of the Safety and Efficacy of DERMASTREAMâ„¢ - ENZYSTREAMâ„¢ System for the Treatment of Chronic Venous Ulcers https://ClinicalTrials.gov/show/NCT00485329 Completed EnzySurge 2009-03-31
NCT00446823 Effectiveness of XCell on Autolytic Debridement of Venous Ulcers https://ClinicalTrials.gov/show/NCT00446823 Completed Xylos Corporation NA
NCT00426972 Trial of Zesteem (Estradiol) in Healing of Split Thickness Skin Graft Donor Sites https://ClinicalTrials.gov/show/NCT00426972 Completed Renovo 2008-07-31
NCT00425178 FGF-1 for Topical Administration for the Treatment of Diabetic or Venous Stasis Ulcers https://ClinicalTrials.gov/show/NCT00425178 Completed CardioVascular BioTherapeutics, Inc. 2006-09-02
NCT00399308 Evaluation of Safety and Activity of Celaderm in Healing Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT00399308 Completed Shire 2008-04-30
NCT00820196 A Trial to Assess the Safety and Activity of Nexagon® for the Treatment of Venous Leg Ulcers (The NOVEL Study) https://ClinicalTrials.gov/show/NCT00820196 Completed OcuNexus Therapeutics, Inc. 2010-02-28
NCT00349700 Wound Dressings Adapted to Wound Exudate and Bacterial Load in Therapy Resistant Large Sized Leg Ulcers https://ClinicalTrials.gov/show/NCT00349700 Completed Ruhr University of Bochum NA
NCT00338923 Wound Healing Effects of HO/03/03 In Patients With Diabetic Neuropathic Plantar and Venous Ulcers, Pilot Study. https://ClinicalTrials.gov/show/NCT00338923 Completed HealOr NA
NCT00301496 Randomized Controlled 8-Week Crossover Evaluation of Compression Bandage Systems for Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT00301496 Completed 3M NA
NCT00270946 Evaluation of Bilayered Cellular Matrix (OrCel) for the Treatment of Venous Ulcers https://ClinicalTrials.gov/show/NCT00270946 Completed Ortec International NA
NCT00235209 A Study to Evaluate the Clinical Effectiveness of a Collagen-ORC Antimicrobial Matrix in Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT00235209 Completed Ethicon, Inc. NA
NCT00207818 Treatment of Cutaneous Ulcers With a Novel Biological Dressing https://ClinicalTrials.gov/show/NCT00207818 Completed CHU de Quebec-Universite Laval 2009-06-30
NCT00202267 Community RCT of the Effectiveness of Two Compression Bandaging Technologies https://ClinicalTrials.gov/show/NCT00202267 Completed Queen’s University 2008-03-31
NCT00184873 Legtest Multi Centre Testing of the Lively Legs Program for Promoting Compliance in Leg Ulcer Patients https://ClinicalTrials.gov/show/NCT00184873 Completed Radboud University 2008-05-31
NCT00000431 Preliminary Testing of New Treatment for Chronic Leg Wounds https://ClinicalTrials.gov/show/NCT00000431 Completed University of Pennsylvania 2008-07-31

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT03070938 PuraPlyâ„¢ Antimicrobial Wound Matrix and Wound Management https://ClinicalTrials.gov/show/NCT03070938 Completed Organogenesis 2017-09-30
NCT03070925 Prospective PuraPlyâ„¢ AM Case Series Study https://ClinicalTrials.gov/show/NCT03070925 Completed Organogenesis 2017-04-30
NCT02889913 When Asking the Indication of a Skin Biopsy From a Patient With a Leg Ulcer in Primary Care? https://ClinicalTrials.gov/show/NCT02889913 Completed Groupe Hospitalier Paris Saint Joseph 2015-07-31
NCT01970657 Observational Study Providing 12 Months of Safety Follow-Up From First Exposure to HP802-247 https://ClinicalTrials.gov/show/NCT01970657 Completed Healthpoint 2015-11-30
NCT01594658 Venous Ulcer Treatment With Foam Versus Conservative Treatment https://ClinicalTrials.gov/show/NCT01594658 Completed Hospital Occidente de Kennedy 2012-02-29
NCT04249661 Differential Effects of Bacteria Colonising Venous Leg Ulcers on Pain and Healing Rates https://ClinicalTrials.gov/show/NCT04249661 Recruiting University Hospital of Limerick 2021-01-09
NCT03744858 The Role of Pyroptosis in Chronic Venous Disease https://ClinicalTrials.gov/show/NCT03744858 Active, not recruiting University of Catanzaro 2019-11-12
NCT03461549 Pressure and Temperature Sensor for Therapeutic Compression Garments https://ClinicalTrials.gov/show/NCT03461549 Recruiting Northwestern University 2021-03-31
NCT03416049 The Effects of Pulsed Elelectro-Magnetic Fields (“PEMF”) in the Treatment of Venous Stasis Leg Ulcers https://ClinicalTrials.gov/show/NCT03416049 Recruiting PEMF Systems, Inc. 2020-06-01
NCT00900029 Safety Follow-Up to HP 802-247-09-015 https://ClinicalTrials.gov/show/NCT00900029 Completed Healthpoint 2011-10-31
NCT01998932 Predictive of Biomarkers of Healing in Chronic Venous Ulceration of the Lower Limb https://ClinicalTrials.gov/show/NCT01998932 Completed Imperial College London 2015-06-30
NCT02577120 Wound Healing Endpoint and Recurrence https://ClinicalTrials.gov/show/NCT02577120 Recruiting Indiana University 2020-12-31

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT03286452 The RESPOND Registry https://ClinicalTrials.gov/show/NCT03286452 Completed Organogenesis 2018-07-15
NCT03257254 Effect of VarIthena on Wound Healing in Venous Leg Ulcers (VLU) https://ClinicalTrials.gov/show/NCT03257254 Active, not recruiting Provensis Ltd 2020-05-31
NCT02813187 Venous Leg Ulcer and Lymphedema Registry https://ClinicalTrials.gov/show/NCT02813187 Enrolling by invitation U.S. Wound Registry 2025-05-31
NCT02280733 A Real World, Observational Registry of Chronic Wounds and Ulcers https://ClinicalTrials.gov/show/NCT02280733 Recruiting U.S. Wound Registry 2025-01-31
NCT02047084 Comparison of Human Allograft to Apligraf for Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT02047084 Enrolling by invitation Solsys Medical LLC 2019-12-31